XARELTO® Plus Low-Dose Aspirin
for PAD

Aspirin has been a trusted medication to help reduce the risk of blood clots that may cause a heart attack, stroke, or cardiovascular death. But due to advanced research, we now know that aspirin alone may not be enough.

XARELTO® is a blood thinner approved by the FDA that, when added to low-dose aspirin, can help reduce the risk of major blood-clotting events like a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke, including in people who have recently had a vascular intervention (a procedure to improve blood flow to the legs).

Aspirin alone may not be enough

Even when you’re following your healthcare professional’s instructions to take aspirin every day and to eat right and stay active, you may still have an underlying risk for blood clots that may cause another unexpected cardiovascular event.

MORE THAN

2X INCREASE

IN HEART ATTACKS, STROKES, & CARDIOVASCULAR DEATHS WITH OR WITHOUT ASPIRIN

While aspirin alone can help reduce your risk for these events, a large study of almost 40,000 people, including those with PAD or coronary artery disease (CAD), showed that even though more than half were taking aspirin, the number of heart attacks, strokes, and cardiovascular deaths more than doubled over a two-year period.*

*According to data from the REACH Registry.

Adding XARELTO® to your low-dose aspirin

XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin (75 mg–100 mg) once daily, is proven to help reduce the risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke in people with peripheral artery disease (a condition where the blood flow to the legs is reduced), and includes people who have recently had a procedure to improve blood flow to the legs, versus aspirin alone.

about_cad_pad_basic_95_85_percent_infographics

In fact, in a clinical trial, almost 95% of people with PAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin, did not have a heart attack, stroke, or die from a cardiovascular event. And, in another clinical trial, almost 85% of people who took XARELTO®, in combination with low-dose aspirin, did not have a heart attack, stroke, poor blood flow in the legs, or amputation after vascular intervention.

The rate of the first event like a stroke, heart attack, or cardiovascular death was 5.1% for people taking XARELTO® plus aspirin vs 6.9% for aspirin alone. Patients were followed for an average of 23 months.

The rate of the first event like a stroke, heart attack, poor blood flow in the legs, and amputation was 15.5% for people taking XARELTO® plus aspirin vs 17.8% for aspirin alone. Patients were followed for an average length of treatment of 30 months.

How XARELTO® works with aspirin

XARELTO® works together with aspirin to help protect you from blood clots that may cause a heart attack, stroke, or cardiovascular death. Think of XARELTO® and aspirin like two members of the same team whose job it is to prevent blood clots from forming and growing. But they each play different positions—aspirin, an antiplatelet blood thinner, helps keep platelets (which are a type of blood cell) from sticking together, and XARELTO®, an anticoagulant blood thinner, helps slow down the blood's clotting process.

A study showed that adding XARELTO® to low-dose aspirin helps further reduce the risk of a heart attack, stroke, and cardiovascular death, compared to aspirin alone.

Bleeding risk with XARELTO® plus low-dose aspirin

While all blood thinners come with a risk of bleeding, around 3% of people taking XARELTO® 2.5 mg with their low-dose aspirin experienced a major bleeding event, such as bleeding into the brain. That represents about a 1% increase in bleeding versus people taking only low-dose aspirin.

But remember, if you and your doctor choose to add XARELTO® to your low-dose aspirin, it’s likely because your doctor believes the benefit of helping to protect you from life-threatening blood clots outweighs your risk of bleeding.

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