XARELTO® Plus Low-Dose Aspirin
for Chronic PAD

Aspirin has been a trusted treatment option to help reduce the risk of blood clots that may cause a heart attack, stroke, or cardiovascular death. But due to advanced research, we now know that aspirin alone may not be enough.

XARELTO® is a blood thinner approved by the FDA that, when added to low-dose aspirin, can help further reduce the risk of blood clots that may cause a serious cardiovascular event like a heart attack, stroke, or cardiovascular death.

Aspirin alone may not be enough

Even when you’re following your healthcare professional’s instructions to take aspirin every day and to eat right and stay active, you may still have an underlying risk for blood clots that may cause another unexpected cardiovascular event.

MORE THAN

2X INCREASE

IN HEART ATTACKS, STROKES, & CARDIOVASCULAR DEATHS WITH OR WITHOUT ASPIRIN

While aspirin alone can help reduce your risk for these events, a large study of almost 40,000 people, including those with PAD or coronary artery disease (CAD), showed that even though more than half were taking aspirin, the number of heart attacks, strokes, and cardiovascular deaths more than doubled over a two-year period.*

*According to data from the REACH Registry.

Adding XARELTO® to your low-dose aspirin

XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin (75 mg–100 mg) once daily, is proven to help further reduce the risk of heart attack, stroke, and cardiovascular death in people with chronic PAD versus aspirin alone.

In fact, in a clinical trial, almost 96% of people with chronic PAD or CAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin, did not have a heart attack, stroke, or die from a cardiovascular event.

The rate of the first event like a stroke, heart attack, or cardiovascular death was 4.1% for people taking XARELTO® plus aspirin vs 5.4% for aspirin alone. Patients were followed for an average of 23 months.

How XARELTO® works with aspirin

XARELTO® works together with aspirin to help protect you from blood clots that may cause a heart attack, stroke, or cardiovascular death. Think of XARELTO® and aspirin like two members of the same team whose job it is to prevent blood clots from forming and growing. But they each play different positions—aspirin, an antiplatelet blood thinner, helps keep platelets (which are pieces of blood cells) from sticking together, and XARELTO®, an anticoagulant blood thinner, helps slow down the blood's clotting process.

Until recently, aspirin had to play defense on its own, but a study showed that adding XARELTO® to the team helps further reduce the risk of a heart attack, stroke, and cardiovascular death, compared to aspirin alone.

Bleeding risk with XARELTO® plus low-dose aspirin

While all blood thinners come with a risk of bleeding, around 3% of people taking XARELTO® 2.5 mg with their low-dose aspirin experienced a major bleeding event, such as bleeding into the brain. That represents about a 1% increase in bleeding versus people taking only low-dose aspirin.

But remember, if you and your doctor choose to add XARELTO® to your low-dose aspirin, it’s likely because your doctor believes the benefit of helping to protect you from life-threatening blood clots outweighs your risk of bleeding.

Savings & Support

Janssen wants to help you explore cost support options for XARELTO®.

Start the Conversation

Choose questions about PAD and XARELTO® to ask at your next doctor’s appointment.

Starting XARELTO®

Understand how to take XARELTO® and what to do if you miss a dose.