XARELTO® vs Warfarin

Both XARELTO® and warfarin are prescribed for similar reasons. While they are both proven to be similarly effective, the differences noted in the below table may have a significant impact on your routine.

  XARELTO® Warfarin (Coumadin®, Jantoven®)
How Medication Works XARELTO® works by blocking Factor Xa (“10a”), an enzyme needed for blood clots to form Warfarin works by interfering with vitamin K and at least 6 blood-clotting factors
Blood Monitoring No regular blood tests
Regular blood tests are not required with XARELTO®
Requires blood tests
Blood tests are required at the start and throughout your treatment
Dietary Restrictions No known dietary restrictions
With XARELTO®, you can continue to eat the healthy foods you enjoy
Dietary restrictions exist
Spinach, cabbage, broccoli, and other foods high in vitamin K can affect how well warfarin works
Drug Interactions There are limited known interactions between XARELTO® and other medications
Please talk to your healthcare professional or see full Prescribing Information for a list of medications that may interact with XARELTO®
There is a broad range of medications that interact with warfarin
Please talk to your healthcare professional about a list of medications that may interact with warfarin

Warfarin and regular blood testing

Not only does warfarin interact with other medicines, alcohol, and certain foods (especially those high in vitamin K), but the initial dosing of warfarin varies widely from person to person based on a number of factors, including age, race, weight, and sex. Because of this, you will need to have regular blood tests—in some cases as often as 1–2 times a week—to ensure your warfarin dose remains safe and effective. Usually, your healthcare professional will refer you to an anticoagulation clinic where you’ll receive a blood test called a prothrombin time test. The result of this test is expressed as your INR (international normalized ratio).

Your INR is a score that represents the time it takes for your blood to clot. If your score is too high, you could have a greater risk of bleeding. Too low, and your risk of getting a dangerous blood clot increases. Frequent testing and adjustments to your warfarin dose will help ensure that your INR stays within the target range. Remember, these blood tests do not monitor anything other than your INR, so you should still work with your healthcare professional to manage your condition.

XARELTO® vs warfarin

See how XARELTO® works compared to warfarin to reduce your risk of blood clots.

I don't have to worry about eating a salad or greens—that's important to me.

Discover the differences that made XARELTO® a better choice for Paul.