What is XARELTO® ?
XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions and no requirements for frequent blood tests.
Taking XARELTO® with low-dose aspirin helps to reduce your risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke.
In fact, in a clinical trial, almost 85% of adults who took XARELTO®, in combination with low-dose aspirin,† did not have a heart attack, stroke, sudden decrease in blood flow in the legs, or amputation after vascular intervention.‡
And, in another clinical trial, almost 95% of adults with chronic PAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin,† did not have a heart attack, stroke, or die from a cardiovascular event.§
Remember, all blood thinners come with a risk of bleeding. In a clinical trial, less than 2% of people taking XARELTO® 2.5 mg twice daily in combination with low-dose aspirin experienced a major bleeding event, such as bleeding into the brain.
And, in another clinical trial, around 3% of people taking XARELTO®, in combination with aspirin, experienced a major bleeding event versus 1% of people taking only low-dose aspirin. That represents about a 1% increase in bleeding versus people taking only low-dose aspirin.
†Low-dose aspirin = 75 mg–100 mg once daily.
‡XARELTO®, in combination with aspirin, reduced the rate of stroke, heart attack, poor blood flow in the legs, and amputation vs aspirin alone (15.5% vs 17.8%). Patients were followed for an average length of treatment of 30 months.
§The rate of the first event like a stroke, heart attack, or cardiovascular death was 5.1% for people taking XARELTO® plus aspirin vs 6.9% for aspirin alone. Patients were followed for an average of 23 months.
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Talk to your doctor about XARELTO®
Use this guide to discuss the risks of cardiac events due to PAD with your doctor, and whether XARELTO® may be right for you.
Take one XARELTO® 2.5 mg tablet twice daily with or without food in combination with low-dose aspirin (75 mg-100 mg) once daily
Tablets shown not actual size
How do you take XARELTO®?
- Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional.
- If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time.
- Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®).
Are there any side effects associated with XARELTO® in adults?
Side effects of XARELTO®:
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Increased risk of bleeding
- You are likely to bruise more easily and it may take longer for the bleeding to stop
Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:
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- Aspirin or aspirin-containing products
- Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
- Warfarin sodium (Coumadin®, Jantoven®)
- Any medicine that contains heparin
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- Clopidogrel (Plavix®)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Other medicines to prevent or treat blood clots
Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional may help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.
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Getting started with XARELTO®?
Discover information about getting started with XARELTO®, savings options, and your condition—all in one helpful starter kit.