What is XARELTO®?
XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions, no requirements for frequent blood tests, and few drug interactions.
Treats DVT and PE
In two clinical studies, almost 98% of adults being treated for a DVT or PE with XARELTO® did not have another one.‡
‡2.1% of patients treated with XARELTO® experienced another DVT vs 3.0% of patients treated with enoxaparin/vitamin K antagonist (EINSTEIN DVT). 2.1% of patients treated with XARELTO® experienced another PE vs 1.8% of patients treated with enoxaparin/vitamin K antagonist (EINSTEIN PE). Patients were followed for an average length of 208 days. People taking XARELTO® to treat a DVT or PE showed a major bleeding rate of 1% with XARELTO® vs 1.7% with enoxaparin and vitamin K antagonist.
Reduces the risk of another DVT and PE from happening again
In another clinical study, almost 99% of adults taking XARELTO® did not have another DVT or PE after 6 months of initial treatment for blood clots.§
§XARELTO® was superior to aspirin in reducing the risk of DVT/PE. After receiving treatment for blood clots for at least 6 months, 1.2% of patients on XARELTO® experienced another DVT or PE vs 4.4% on aspirin at 1 year (EINSTEIN CHOICE). Less than 1% of patients taking XARELTO® experienced major bleeding, which is similar to the rate of major bleeding in patients taking aspirin to reduce their risk of recurrent DVT or PE.
How do you take XARELTO®?
For DVT or PE, take XARELTO® 1 or 2 times a day as prescribed by your doctor.
- If your doctor prescribed the 10-mg dose, take XARELTO® with or without food.
- If your doctor prescribed the 15-mg or 20-mg dose, take XARELTO® with food at the same time each day.
- If you take XARELTO® twice a day and miss a dose, take it as soon as you remember on the same day. You may take 2 doses at the same time to make up for the missed dose. Take your next dose at your regularly scheduled time.
- If you take XARELTO® once a day and miss a dose, take it as soon as you remember on the same day. Take your next dose at your regularly scheduled time.
- Do not change your dose or stop taking XARELTO® unless your doctor tells you to. Your doctor may change your dose if needed.
- Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®).
Are there any side effects associated with XARELTO® in adults?
Side effects of XARELTO®:
Increased risk of bleeding
- You are likely to bruise more easily and it may take longer for the bleeding to stop
Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:
- Aspirin or aspirin-containing products
- Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
- Warfarin sodium (Coumadin®, Jantoven®)
- Any medicine that contains heparin
- Clopidogrel (Plavix®)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Other medicines to prevent or treat blood clots
Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional will help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.