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XARELTO® for CAD | XARELTO® (rivaroxaban)
*Direct Oral Anticoagulant (DOAC).
CAD=coronary artery disease.

What is XARELTO®?

XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions and no requirements for frequent blood tests.

Risk factor cad

XARELTO®, in combination with low-dose aspirin, is the only drug in its class§ indicated to help reduce the risk of heart attack, stroke, or cardiovascular death in adults with CAD.


In fact, in a clinical trial, almost 96% of adults with CAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin, did not have a heart attack, stroke, or die from a cardiovascular event.||

Remember, all blood thinners come with a risk of bleeding. Around 3% of people taking XARELTO® 2.5 mg twice daily in combination with low-dose aspirin experienced a major bleeding event, such as bleeding into the brain, compared to around 2% of people taking low-dose aspirin alone.

Low-dose aspirin = 75 mg–100 mg once daily.

§Direct Oral Anticoagulant (DOAC).

||The rate of the first event like a stroke, heart attack, or cardiovascular death was 4.2% for people taking XARELTO® plus aspirin vs 5.6% for aspirin alone. Patients were followed for an average of 23 months.

talk to your doctor

Talk to your doctor about XARELTO®

Use this guide to discuss the risks of cardiac events due to CAD with your doctor, and whether XARELTO® may be right for you.

Take one XARELTO® 2.5 mg tablet twice daily with or without food in combination with low-dose aspirin (75 mg-100 mg) once daily


Tablets shown not actual size

How do you take XARELTO®?

  • Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional
  • If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time
  • Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®)

Are there any side effects associated with XARELTO® in adults?

Side effects of XARELTO®:

  • Increased risk of bleeding
    • You are likely to bruise more easily and it may take longer for the bleeding to stop

Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:

    • Aspirin or aspirin-containing products
    • Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
    • Warfarin sodium (Coumadin®, Jantoven®)
    • Any medicine that contains heparin
    • Clopidogrel (Plavix®)
    • Selective serotonin reuptake inhibitors (SSRIs)
    • Serotonin norepinephrine reuptake inhibitors (SNRIs)
    • Other medicines to prevent or treat blood clots

Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional will help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.

getting started

Getting started with XARELTO®?

Discover information about getting started with XARELTO®, savings options, and your condition—all in one helpful starter kit.