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XARELTO® For AFib | XARELTO® (rivaroxaban)

What is XARELTO®?

XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions and no requirements for frequent blood tests.

Risk factors image

XARELTO® significantly reduces the risk of stroke in people with AFib not caused by a heart valve problem.


In a clinical trial, over 96% of people who took XARELTO® remained stroke-free.§

Pill bottle

XARELTO® offers 24-hour stroke-risk reduction with just one pill a day.*

In a clinical trial comparing XARELTO® to warfarin for reducing the risk of AFib-related stroke, 99% of people taking XARELTO® did not experience bleeding into the brain, which can be serious. However, overall major bleeding was similar and gastrointestinal bleeding was about 1% higher.

*Taken with the evening meal.
DOACs=direct oral anticoagulants.

AFIB=atrial fibrillation 
§Rate of first occurrence of stroke was 3.8% for XARELTO® versus 4.3% for warfarin.

Talk to your doctor

Talk to your doctor about XARELTO®

Use this guide to discuss the risks associated with AFib-related stroke with your doctor, and whether XARELTO® may be right for you.

Take one 15-mg or 20-mg tablet once a day, with dinner


Tablets shown not actual size

How do you take XARELTO®?

  • Take one tablet once a day with the evening meal
  • If you miss a dose of XARELTO®, take it as soon as you remember on the same day. Take your next dose at your regularly scheduled time
  • Do not change your dose or stop taking XARELTO® unless your doctor tells you to. Your doctor may change your dose if needed
  • Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®)

Are there any side effects associated with XARELTO® in adults?

Side effects of XARELTO®:

  • Increased risk of bleeding
    • You are likely to bruise more easily and it may take longer for the bleeding to stop

Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:

    • Aspirin or aspirin-containing products
    • Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
    • Warfarin sodium (Coumadin®, Jantoven®)
    • Any medicine that contains heparin
    • Clopidogrel (Plavix®)
    • Selective serotonin reuptake inhibitors (SSRIs)
    • Serotonin norepinephrine reuptake inhibitors (SNRIs)
    • Other medicines to prevent or treat blood clots

Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional will help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.

getting started

Getting started with XARELTO®?

Discover information about getting started with XARELTO®, savings options, ongoing support, and your condition—all in one helpful starter kit.