What is XARELTO® ?
XARELTO® belongs to a group of medicines called direct oral anticoagulants, or DOACs for short. Like other DOACs, XARELTO® has no known dietary restrictions, no requirements for frequent blood tests, and few drug interactions.
Adding XARELTO® to your daily aspirin helps to reduce your risk of a sudden decrease in blood flow to the legs, major amputation, serious heart problems, or stroke.
In fact, in a clinical trial, almost 95% of adults with chronic PAD taking XARELTO® 2.5 mg twice daily, in combination with low-dose aspirin,* did not have a heart attack, stroke, or die from a cardiovascular event.†
And, in another clinical trial, almost 85% of adults who took XARELTO®, in combination with low-dose aspirin,* did not have a heart attack, stroke, sudden decrease in blood flow in the legs, or amputation after vascular intervention.‡
*Low-dose aspirin = 75-mg–100-mg tablet once daily.
†Rate of first event (heart attack, stroke, cardiovascular death) was 5.1% for XARELTO® plus aspirin versus 6.9% for aspirin alone. Patients were followed for an average of 23 months.
‡The rate of the first event like a stroke, heart attack, poor blood flow in the legs, and amputation was 15.5% for people taking XARELTO® plus aspirin vs 17.8% for aspirin alone. Patients were followed for an average length of treatment of 30 months.
Take one XARELTO® 2.5 mg tablet twice daily with or without food in combination with low-dose aspirin (75 mg-100 mg) once daily
Tablets shown not actual size
How do you take XARELTO®?
- Take XARELTO® 2.5 mg twice daily with or without food in combination with aspirin 75 mg–100 mg once daily as instructed by your healthcare professional.
- If you miss a dose of XARELTO®, take your next 2.5 mg dose at your regularly scheduled time.
Remember, there are no known dietary restrictions, unlike warfarin (Coumadin®).
Are there any side effects associated with XARELTO® in adults?
Side effects of XARELTO®:
Increased risk of bleeding
- You are likely to bruise more easily and it may take longer for the bleeding to stop
Your risk of bleeding increases if you take XARELTO® with other medicines that also increase your risk of bleeding, such as:
- Aspirin or aspirin-containing products
- Long-term (chronic) use of non-steroidal anti-inflammatory drugs (NSAIDs)
- Warfarin sodium (Coumadin®, Jantoven®)
- Any medicine that contains heparin
- Clopidogrel (Plavix®)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin norepinephrine reuptake inhibitors (SNRIs)
- Other medicines to prevent or treat blood clots
Always tell your healthcare professional if you experience any side effects while taking XARELTO®—keeping an open and honest conversation going with your healthcare professional may help you get the best care. You can use the Doctor Discussion Guide to help inform your conversation.