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Frequently Asked Questions | XARELTO® (rivaroxaban)

Answering Your Questions

Each day, people like you search online for answers to questions about XARELTO®. So we wanted to take this opportunity to answer some of them. Below, you’ll find answers to the questions people ask the most.


XARELTO® is a blood thinner that treats and helps prevent blood clots that are related to certain conditions involving the heart and blood vessels.

XARELTO® lowers your blood’s ability to clot by selectively blocking one of the clotting factors found in your blood—an enzyme called Factor Xa (“10a”). Learn more.

If you take XARELTO®, regular blood tests are not needed to see if XARELTO® is working, to check your blood-thinning levels (international normalized ratio, or INR), or to change your medication dose.*

It has been shown that the effect of XARELTO® on your body’s blood-clotting function is the same regardless of age, race, weight, sex, or dietary changes. There are also limited known interactions between XARELTO® and other medications.

*Certain patients with impaired kidney function may be monitored by their healthcare professional and have their dose adjusted as necessary.

XARELTO® has fewer drug interactions than older medicines like warfarin. Not only does warfarin interact with other medicines, alcohol, and certain foods (especially those high in vitamin K, like leafy greens), but the initial dosing of warfarin varies widely from person to person based on a number of factors, including age, race, weight, and sex. Because of this, when taking warfarin, you will need to have regular blood tests—in some cases as often as 1 or 2 times a week—to ensure your warfarin dose remains safe and effective.

You should always tell your healthcare professional about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements—especially if you take ketoconazole, ritonavir, erythromycin, carbamazepine, phenytoin, rifampin, or St. John’s wort.

Unlike warfarin (Coumadin®), XARELTO® has no known dietary restrictions. You do not have to adjust your intake of leafy greens and other foods high in vitamin K, as they don't affect how XARELTO® works.

Under the supervision of your healthcare professional, like other prescription medicines, XARELTO® may be taken with other medications. Always tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements—especially if you take ketoconazole, ritonavir, carbamazepine, phenytoin, rifampin, erythromycin, or St. John’s wort.

It’s also important to note that, as with all blood thinners, you have a higher risk of bleeding if you take XARELTO® with other medicines that also increase your risk of bleeding, such as aspirin, non-steroidal anti-inflammatory drugs (NSAIDs), warfarin, any medicine that contains heparin, clopidogrel (Plavix®), selective serotonin reuptake inhibitors (SSRIs) or serotonin norepinephrine reuptake inhibitors (SNRIs), or other medicines to prevent or treat blood clots.

Like all blood thinners, XARELTO® can cause bleeding, which can be serious, and in rare cases, can be life threatening. Be sure to take XARELTO® exactly as prescribed, and do not stop taking XARELTO® without talking to the healthcare professional who prescribes it for you. You should discuss all potential benefits and risks with your healthcare professional.

The list price of XARELTO® is $516 per month.1 But remember, how much you will have to pay for XARELTO® depends on your health plan coverage. If you have commercial or private insurance and are being treated with XARELTO®, except if you are taking XARELTO® 10 mg after a recent non-surgical hospitalization or because you have recently undergone knee or hip replacement surgery, you may be eligible for savings through the Janssen CarePath Savings Program for XARELTO®.

If you have government insurance, or no prescription coverage, Janssen CarePath can provide information about other resources that may be able to help with your out-of-pocket medication costs. Learn more about your savings options.

1.How much you will pay each time you fill your prescription is determined by your health or prescription insurance carrier and your specific insurance policy. Information listed is accurate as of 01/19/2022. Information for Medicaid and Medicare Part D out-of-pocket costs are based on publicly available benefit design for 2022 plan year. List price does not reflect a patient's out-of-pocket cost and does not include samples, vouchers, the cost of administering the medication, or pharmacy fees.

There is no XARELTO® coupon. How much you will have to pay for XARELTO® depends on your health plan coverage. We can also provide information on other resources that may help you save on XARELTO®.

Visit for information on affordability programs and independent foundations that may have funding available to help you with medication costs for XARELTO®.

Independent co-pay assistance foundations have their own rules for eligibility. We cannot guarantee a foundation will help you. We only can refer you to a foundation that supports your disease state. This information is provided as a resource for you. We do not endorse any particular foundation.

Other Resources

The Johnson & Johnson Patient Assistance Foundation, Inc. (JJPAF) is an independent, nonprofit organization. JJPAF gives eligible patients free prescription medicines donated by Johnson & Johnson companies. You may be eligible if you don't have insurance, if your medicine is not covered by insurance, or if you have Medicare coverage and can't pay for your medicine.

Want to see if you qualify? Get an application at

Questions? Call 800-652-6227 (Monday through Friday, 9:00 AM to 6:00 PM ET).

Do everything you can to fill your prescription before you run out. Skipping or stopping XARELTO® may increase your risk of having a DVT or PE blood clot or stroke. If you’ve been prescribed XARELTO®, you can set up monthly refill reminders when you register for Janssen CarePath, which offers support and educational resources for people taking XARELTO®.

If you need to have surgery or surgical dental procedures, be sure to tell your surgeon, dentist, or other healthcare professionals that you are taking XARELTO®. You should also talk to the healthcare professional who prescribed XARELTO® for you. Only they can tell you whether, and for how long, you may need to stop. If you do need to stop taking XARELTO®, it is typically stopped at least 24 hours before your procedure.

When starting XARELTO®, it takes 2–4 hours for it to reach its full blood-thinning effect, and it leaves your system more quickly than warfarin—typically in about 24 hours. Compared to warfarin, which can take 3–4 days to reach its full blood-thinning effect and up to 7 days to leave your system, XARELTO® may be an option for people who plan to have surgery or surgical dental procedures.

XARELTO® was developed together by Janssen and Bayer. They continue to develop XARELTO® to treat and help reduce the risk of blood clot–related events in different conditions.