XARELTO® is different from other blood thinners.

XARELTO® is a prescription anticoagulant, or blood-thinning medication, proven to:

Learn how blood thinners work and why you might need one.

XARELTO® reduces each of these risks with:

Prescribed Blood
Thinner in Its Class.

More than 11 million prescriptions in the U.S. and growing.

XARELTO® has been approved for a variety of uses. More than 11 million prescriptions have been written in the U.S. alone to treat or help reduce the risk of DVT and PE blood clots and strokes. In fact, XARELTO® is now the most prescribed blood thinner in its class in the country.

Learn how XARELTO® can help you. Choose your health condition:

XARELTO® doesn’t require regular blood monitoring.

XARELTO® has been shown to deliver a predictable blood thinning effect. In clinical studies, involving more than 55,000 people, regular blood monitoring was not required. With warfarin, (e.g., Coumadin®), another medicine that helps reduce the risk of DVT and PE blood clots and strokes, blood-thinning levels (e.g., INR) can change based on age, race, weight, gender, and dietary changes. These are just a few of the reasons why regular blood monitoring is necessary with warfarin. The predictable effect of XARELTO®, however, means that regular blood tests aren’t needed to see if it’s working, check your levels, or change your medication dose. So you don’t have to plan your schedule around a blood monitoring routine when you take XARELTO®.

XARELTO® has no known dietary restrictions.

XARELTO® doesn’t interact with vitamin K like warfarin does. So you can enjoy leafy green vegetables and other foods rich in vitamin K whenever you like, without having to worry about it changing the way XARELTO® works.

XARELTO® doesn’t need frequent dosage adjustments.

For many people who take XARELTO®, there are no dosage adjustments to keep track of.

Most people with AFib who take XARELTO® will start on and stay with the same dose throughout their treatment — once a day with the evening meal. People with kidney problems, however, may need to have their dosage adjusted while taking XARELTO®.

Most people starting on XARELTO® to treat and help prevent DVT and PE have just one scheduled dosage adjustment — switching from taking one XARELTO® 15-mg tablet twice a day with food to one 20-mg tablet once a day with food on their 22nd day of treatment.

People who’ve had hip or knee replacement surgery will start on and stay with the same dose of XARELTO® following surgery and take it once a day, with or without food, as prescribed by their doctor.

Like all blood thinners, XARELTO® has benefits and risks.

Facts about XARELTO® vs. warfarin (e.g., Coumadin®)*

XARELTO® (rivaroxaban)

warfarin (e.g., Coumadin®)

How Medication Works
XARELTO® works by blocking Factor Xa (“10a”), an enzyme needed for blood clots to form.
Warfarin works by interfering with vitamin K, a nutrient needed for blood clots to form.
Blood Monitoring
No regular blood tests.
Regular blood tests are not needed with XARELTO®.
Requires regular blood tests.
Blood tests are required at the start and throughout your treatment.
Dietary Restrictions
No known dietary restrictions.
With XARELTO® you can continue to eat the healthy foods you enjoy.
Dietary restrictions exist.
Spinach, cabbage, broccoli, and other foods high in vitamin K can affect how well warfarin works.
Dosing for AFib
No regular dosage adjustments.
Most people with AFib will stay with the same dosage throughout their treatment. People with kidney problems, however, may have to have their dosage adjusted while taking XARELTO® .
Dosage adjustments may be needed.
Your dosage may be adjusted at various times during your treatment based on the results of regular blood tests.
Dosing for DVT or PE
One scheduled dosage adjustment.
Most people with DVT or PE, starting on XARELTO® take 15 mg twice a day with food for the first 21 days, then switch to 20 mg once a day with food on the 22nd day.
Dosage adjustments may be needed.
Your dosage may be adjusted at various times during your treatment based on the results of regular blood tests.
Dosing After Hip or Knee Replacement Surgery
No regular dosage adjustments.
Following surgery, most people will stay with the same dosage throughout their treatment.
Dosage adjustments may be needed.
Your dosage may be adjusted at various times during your treatment based on the results of regular blood tests.

For people with AFib currently well managed on warfarin, there is limited information on how XARELTO® and warfarin compare in reducing the risk of stroke.

 

XARELTO® is a prescription medicine used to reduce the risk of stroke and blood clots in people with atrial fibrillation, not caused by a heart valve problem. For patients currently well managed on warfarin, there is limited information on how XARELTO® and warfarin compare in reducing the risk of stroke.

XARELTO® is also a prescription medicine used to treat deep vein thrombosis and pulmonary embolism, and to help reduce the risk of these conditions occurring again.

XARELTO® is also a prescription medicine used to reduce the risk of forming a blood clot in the legs and lungs of people who have just had knee or hip replacement surgery.

 

WHAT IS XARELTO®?

Important Safety Information